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Daytime and Nighttime Sinus CongestionPE

Dosage form
KIT
Labeler
CVS PHARMACY
Label updated
2025-07-21
Retrieved
2026-09-07
Active ingredients
DIPHENHYDRAMINE HYDROCHLORIDE · PHENYLEPHRINE HYDROCHLORIDE
View original label and images on DailyMed ↗
Active ingredient (in each tablet) (Sinus Day)

Phenylephrine HCl 10 mg

Purpose

Nasal decongestant

Active ingredients (in each tablet) (Sinus Night)

Diphenhydramine HCl 25 mg
Phenylephrine HCl 10 mg

Purpose

Antihistamine
Nasal decongestant

Uses
  • temporarily relieves these symptoms due to hay fever or other upper respiratory allergies:
    • nasal congestion
    • sneezing (Nighttime only)
    • runny nose (Nighttime only)
    • itchy, watery eyes (Nighttime only)
    • itching of the nose or throat (Nighttime only)
  • temporarily relieves these symptoms due to the common cold:
    • nasal congestion
    • sneezing (Nighttime only)
    • runny nose (Nighttime only)
  • temporarily relieves sinus congestion and pressure
Warnings

Do not use

  • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
  • with any other product containing diphenhydramine, even one used on skin (Nighttime only)

Ask a doctor before use if you have

  • heart disease
  • diabetes
  • thyroid disease
  • high blood pressure
  • difficulty in urination due to enlargement of the prostate gland
  • a breathing problem such as emphysema or chronic bronchitis (Nighttime only)
  • glaucoma (Nighttime only)

Ask a doctor or pharmacist before use if you are

taking sedatives or tranquilizers. (Nighttime only)

When using this product

  • do not exceed recommended dosage
  • excitability may occur, especially in children (Nighttime only)
  • marked drowsiness may occur (Nighttime only)
  • alcohol, sedatives, and tranquilizers may increase drowsiness (Nighttime only)
  • avoid alcoholic beverages (Nighttime only)
  • use caution when driving a motor vehicle or operating machinery (Nighttime only)

Stop use and ask a doctor if

  • symptoms do not improve within 7 days or occur with fever
  • nervousness, dizziness, or sleeplessness occur

If pregnant or breast-feeding,

ask a health professional before use.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away.

Read each section carefully. Do not take DAYTIME and NIGHTTIME products at the same time.

Directions
  • adults and children 12 years and over
    • take 1 tablet every 4 hours
    • do not take more than 6 tablets in 24 hours
  • children under 12 years: do not use
Other information
  • each tablet contains: calcium 25 mg (Nighttime only)
  • TAMPER EVIDENT: DO NOT USE IF OUTER PACKAGE IS OPENED OR BLISTER IS TORN OR BROKEN
  • store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F)
  • see end flap for expiration date and lot number
Inactive ingredients (Daytime only)

croscarmellose sodium, dextrose monohydrate, dibasic calcium phosphate dihydrate, FD&C red #40, lecithin, magnesium stearate, maltodextrin, microcrystalline cellulose, silicon dioxide, sodium carboxymethylcellulose, sodium citrate dihydrate, titanium dioxide

Inactive ingredients (Nighttime only)

croscarmellose sodium, dibasic calcium phosphate dihydrate, FD&C blue #1 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polydextrose, polyethylene glycol, silicon dioxide, stearic acid, titanium dioxide, triacetin

Questions or comments?

1-800-426-9391

Principal display panel

♥CVSHealth®

Compare to the active ingredients in
Sudafed PE® Sinus Congestion Daytime and Nighttime*

DAYTIME - Non-Drowsy
Sinus
Congestion PE

PHENYLEPHRINE HCI
Nasal decongestant

Relieves:
Nasal congestion

Actual Size

12 TABLETS

NIGHTTIME
Sinus
Congestion PE

DIPHENHYDRAMINE HCI
Antihistamine
PHENYLEPHRINE HCI
Nasal decongestant

Relieves:
Nasal congestion
Runny nose

Actual Size

8 TABLETS

20 TOTAL TABLETS

TAMPER EVIDENT: DO NOT USE IF PACKAGE IS OPENED OR IF BLISTER
UNIT IS TORN, BROKEN OR SHOWS ANY SIGNS OF TAMPERING

*This product is not manufactured or distributed by Johnson & Johnson Corporation,
owner of the registered trademark Sudafed PE® Sinus Congestion Daytime and
Nighttime.                                  50844                REV0820B45348509

Distributed by: CVS Pharmacy, Inc.
One CVS Drive, Woonsocket, RI 02895
© 2021 CVS/pharmacy
CVS.com® 1-800-SHOP CVS
V-19849

CVS® Quality
Money Back Guarantee

[Image in the official label — see DailyMed source]

DailyMed Set ID: 5734844f-0e94-4fc8-b17c-ca3285dc62c9 · Version 9
NDC: 69842-938