Acetaminophen, Aspirin and Caffeine

Active ingredients (in each caplet)                                                          Purposes
Acetaminophen USP, 250 mg...............................................................Pain reliever
Aspirin USP, 250 mg (NSAID*).............................................................Pain reliever
Caffeine USP, 65 mg........................................................................Pain reliever aid
*nonsteroidal anti-inflammatory drug

• temporarily relieves minor aches and pains due to:
• headache 
• a cold
• arthritis 
• muscular aches
• toothache
• premenstrual & menstrual cramps

Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.

Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:

• skin reddening
• blisters
• rash. If a skin reaction occurs, stop use and seek medical help right away.

Allergy alert: Aspirin may cause a severe allergic reaction which may include:

• hives 
• facial swelling 
• asthma (wheezing)
• shock.

Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take

• more than 8 caplets in 24 hours, which is the maximum daily amount
• with other drugs containing acetaminophen 
• 3 or more alcoholic drinks every day while using this product.

Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you

• are age 60 or older 
• have had stomach ulcers or bleeding problems
• take a blood thinning (anticoagulant) or steroid drug 
• take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) 
• have 3 or more alcoholic drinks every day while using this product. 
• take more or for a longer time than directed.

Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally, rapid heart beat.

• if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
• with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.

Ask a doctor before use if 

• you have liver disease 
• stomach bleeding warning applies to you
• you have a history of stomach problems, such as heartburn
• you have high blood pressure, heart disease, liver cirrhosis, or kidney disease 
• you are taking a diuretic 
• you have asthma

Ask a doctor or pharmacist before use if you are

• taking a prescription drug for:
• diabetes 
• gout 
• arthritis 
• taking any other drug, or are under a doctor's care for any serious condition 
• taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer.

Stop use and ask a doctor if

• an allergic reaction occurs. Seek medical help right away. 
• you experience any of the following signs of stomach bleeding:
• feel faint
• vomit blood
• have bloody or black stools 
• have stomach pain that does not get better 
• ringing in the ears or loss of hearing occurs
• pain gets worse or lasts for more than 10 days
• fever gets worse or lasts for more than 3 days
• redness or swelling is present
• any new symptoms occur. These could be signs of a serious condition

If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

• do not take more than directed
• drink a full glass of water with each dose
• adults and children 12 years and over: take 2 caplets every 6 hours. Do not take more than 8 caplets in 24 hours.
• children under 12 years: ask a doctor

Other information

• store at 25°C (77°F) excursions permitted between 15°-30°C (59°-86°F)
• close cap tightly after use
• read all product information before using.

Colloidal silicon dioxide , hypromellose, microcrystalline cellulose , polyethylene glycol, povidone, pregelatinized starch, stearic acid, talc

Questions and comments? Call 1-844-474-7464

Distributed by:
Rising Pharma Holdings, Inc.
East Brunswick, NJ 08816 Made in India Mfg. Lic. No.: G/25/1362

Issued: 09/2025
S-066

⁺This product is not manufactured or distributed by the owner of the registered trademark Excedrin^® Extra Strength

EXTRA STRENGTH Acetaminophen, Aspirin (NSAID) and Caffeine
250mg/250mg/65mg

NDC 57237-348-01

100 Caplets

[Image in the official label — see DailyMed source]