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US · Over-the-counter medicine

Pain ReliefPM

Dosage form
TABLET, FILM COATED
Labeler
HyVee Inc
Label updated
2026-07-16
Retrieved
2026-09-07
Active ingredients
ACETAMINOPHEN · DIPHENHYDRAMINE HYDROCHLORIDE
View original label and images on DailyMed ↗
Active ingredients (in each caplet)

Acetaminophen 500 mg

Diphenhydramine HCl 25 mg

Purpose

Pain reliever

Nighttime sleep-aid

Uses

temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness

Warnings

Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take

  • •more than 4,000 mg of acetaminophen in 24 hours
  • •with other drugs containing acetaminophen
  • •3 or more alcoholic drinks every day while using this product

Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:

  • •skin reddening
  • •blisters
  • •rash

If a skin reaction occurs, stop use and seek medical help right away.

Do not use

  • •in children under 12 years of age
  • •with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
  • •with any other product containing diphenhydramine, even one used on skin
  • •if you have ever had an allergic reaction to this product or any of its ingredients

Ask a doctor before use if you have

  • •liver disease
  • •glaucoma
  • •trouble urinating due to an enlarged prostate gland
  • •a breathing problem such as emphysema or chronic bronchitis

Ask a doctor or pharmacist before use if you are

  • •taking the blood thinning drug warfarin
  • •taking sedatives or tranquilizers

When using this product

  • •drowsiness will occur
  • •avoid alcoholic drinks
  • •do not drive a motor vehicle or operate machinery

Stop use and ask a doctor if

  • •new symptoms occur
  • •sleeplessness lasts continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness.
  • •pain gets worse or lasts more than 10 days
  • •fever gets worse or lasts more than 3 days
  • •redness or swelling is present

These could be signs of a serious condition.

If pregnant or breast-feeding,

ask a health professional before use.

Keep out of reach of children.

Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

Directions
  • do not take more than directed (see overdose warning)
take 2 caplets at bedtime
  • do not take more than 2 caplets of this product in 24 hours

    adults and children

    12 years and over

    children under

    12 years

    do not use

    Inactive ingredients

    carnauba wax, crospovidone, FD&C blue #1 aluminum lake, FD&C blue #2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, povidone, pregelatinized starch, sodium starch glycolate, stearic acid, titanium dioxide

    Questions?

    1-800-289-8343

    Principal Display Panel

    HyVee®

    Compare To Extra Strength Tylenol® PM Active Ingredients

    Pain Relief PM

    Extra Strength

    Acetaminophen 500 mg, Diphenhydramine HCl 25 mg

    Pain Reliever/Nighttime Sleep-Aid

    actual size

    • For Adults

    • Non-Habit Forming

    50 CAPLETS

    [Image in the official label — see DailyMed source]

    [Image in the official label — see DailyMed source]

    DailyMed Set ID: 4f45a750-1220-4a81-801e-bf08c9d117d6 · Version 7
    NDC: 42507-437